The cell cycle is regulated by the following microRNAs: Let-7 with LIN28 and ABCB1 as target genes,
which are downregulated in cancer cells resulting in upregulation of LIN28 results in supporting RAS,
MYC and HMGA2. Mir-21 with PTEN as a target gene, which is upregulated in cancer cells resulting
in promotion of PI3K/AKT signaling activation through directly inhibiting PTEN expression, and with
PDCD4 as target genes which is upregulated in cancer cells. MiR-221/222 with PTEN as a target
gene, which is upregulated in cancer cells resulting in promotion of AKT/NF-κβ/COX-2 pathway by
targeting PTEN. MiR-93 with JAK1, SOX4, STAT3, AKT, EZH1, HMGA2, which are upregulated in
cancer cells resulting in proliferation regulation. MiR-16 with BMI1 as a target gene which is
upregulated in cancer cells resulting in inhibition of DNA repair. MiR-34 with CDK4, CDK6, NOTCH1
which are downregulated in cancer cells resulting in p53 regulation, and with BCL2, NOTCH1/2 as
target genes which are downregulated in cancer cells, with Cyclin D1, CDK4, CDK6, c-MET, CD44 as
target genes which are downregulated in cancer cells. MiR-200 with ZEB1, ZEB2, WNT-signaling as
target genes which aer downregulated in cancer cells resulting in EMT reduction MiR-494-3p with
PAK as target genes which is downregulated in cancer cells resulting in inhibition of proliferation. MiR-
365 with BCL2 as target gene which is upregulated in cancer cells resulting in apoptosis inhibition.
MiR-31 with HDCA2 CDK2 as target genes which are downregulated in cancer cells resulting in
induction of p16 and p21 and repression of cyclin D, CDK4, CDK2. MiR-26a with EZH2 as target
genes which is upregulated in cancer cells resulting in EMT reduction. MiR-150 with GAB1 as target
gene which is downregulated in cancer cells. MiR-203 with ZEB1, ZEB2 as target genes which are
downregulated in cancer cells. MiR-17-92 with p21, p57, TBX3 as target genes which are
downregulated in cancer cells. MiR-100 with CDK6, RB1, mTOR as target genes which are
downregulated in cancer cells, and with CDK6, RB1, mTOR as target genes which are down
regulated in cancer cells. MiR-221/222 with p27/Kip1 as target genes which are upregulated in cancer
cells. MiR -17-92 with p21, p57, TBX3 as target genes which are downregulated in cancer cells, partly
participating in maintaining stemness characteristics of stem cancer cells. MiR -124 with CDK6 as
target gene which is upregulated in cancer cells. MiR -137 with CDK6 as target gene which is
upregulated in cancer cells. MiR -128 with BMI1 as target gene which is upregulated in cancer cells.
MiR 23b with HMGA2 as target gene which is upregulated in cancer cells. MiR -125b with CDK6,
E2F3, CDC25A as target genes which are downregulated in cancer cells. MiR -605 with LATS2 as
target gene which is upregulated in cancer cells. MiR -15a/ miR-16 with RB as target gene which is
upregulated in cancer cells